Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections including Impetigo, Cellulitis, and Abscess

AC Bowen; JR Carapetis; BJ Currie; V Fowler; HF Chambers; SYC Tong

Journal article

Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections including Impetigo, Cellulitis, and Abscess

AC Bowen, JR Carapetis, BJ Currie, V Fowler, HF Chambers, SYC Tong

Open Forum Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2017

DOI: 10.1093/ofid/ofx232

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Abstract

Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a systematic review of clinical trials and observational studies that address the utility of SXT for SSTI treatment, caused by either GAS or Staphylococcus aureus, including methicillin-resistant (MRSA). We identified 196 studies, and 15 underwent full text review by 2 reviewers. Observational studies, which mainly focused on SSTI due to S aureus, supported the use of SXT when compared..

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University of Melbourne Researchers

Steven Tong Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

A.C.B. is the recipient of an Australian National Health and Medical Research Council (NHMRC) early career fellowship scholarship (1088735). S.Y.C.T. is the recipient of an NHMRC Career Development Fellowship (1065736). This work is supported by NHMRC project grant 1131932 (the HOT NORTH initiative).